Depressive Symptoms
B12 deficiency is also associated with an increased risk of depression. Low B12 levels lead to elevated homocysteine, a sulfur-containing amino acid, which contributes to depression by causing oxidative stress, DNA damage, and cell death. A 2020 study involving 132 children and teenagers found that those with depression had lower B12 levels and higher homocysteine levels than those without depression. Besides depressive symptoms, B12 deficiency can also lead to other mental health issues like psychosis and mood disorders. [5]
Paresthesia in Hands and Feet
Paresthesia, or a burning and pins-and-needles sensation in the hands and feet, is a symptom reported by many individuals with B12 deficiency. This symptom can be particularly alarming as it overlaps with those of diabetic neuropathy, a condition caused by nerve damage from high blood sugar levels. The similarity between these symptoms can lead to misdiagnosis, especially in individuals with diabetes who are at a higher risk for B12 deficiency due to the use of metformin, which interferes with B12 absorption. Regular screening for B12 deficiency is recommended for those taking metformin to prevent misdiagnosis and ensure appropriate treatment.
